The purpose of this research is to highlight changes in human development status of districts of Pakistan during the period between 1998 and 2005. The standard summary measure, Human Development Index (HDI) proposed by UNDP, is applied at the district level. District HDIs, estimated for both periods will provide an indication of existing trends in regional disparities in terms of economic development as well as in the education and health status of districts. The findings will facilitate district governments for future planning and resource allocation. The estimated HDIs indicate an overall annual growth of 3 percent during 1998-2005. On average, the highest growth rates are observed in NWFP districts mainly due to progress in the education sector.